Santiago to La Serena bus is a popular way of traveling. There are up to 104 daily bus departures available, including 51 night buses. The earliest bus departs from Santiago bus station at 07:00h, arriving at La Serena bus station at 13:05h the same day. While latest bus departs at 23:59h, arriving at 06:30h the following day.
Departure station and country
Santiago, Chile
Arrival station and country
La Serena, Chile
Travel Distance
473 km
Average Trip Duration
07h 02min
Total Departures
104
Popular Operators
FlixBus
Lowest Price
€10
Transportation Options
Bus
Table Of Contents
Popular Departures
Below you will find some of the most popular bus departures from Santiago to La Serena:
The shortest travel distance between Santiago and La Serena is 473 km.
The fastest bus which departs at 18:30 has a travel time of 05:30h.
The longest travel time on the route is 08:35h.
Depending on the selected departure, the following amenities are available: air condition, wifi and toilet.
You can book tickets in advance to secure your seat, especially during peak travel times.
Overnight buses
If you want to travel overnight and save money on accommodation or arrive in La Serena earlier, there
are over 50 night buses from Santiago to La Serena.
The overnight buses depart between 18:00 and 23:59 and arrive between 00:15 and 06:30
the following day.
Below are the most popular night departures to La Serena:
Bus companies operating the Santiago to La Serena route
FlixBus is the carrier operating this route. This company has not been rated yet by travelers.
Departure and arrival stations
For more details about Santiago or La Serena bus stations, including general information, and other popular routes, you can check the links below.
If you've traveled from Santiago to La Serena, and you want to share your experience, leave a review for the route and let us know what part of your journey was the best, and what needs improvement.
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Other popular destinations from Santiago
If you're wondering what other destinations you can visit when traveling from Santiago, below are some of the most popular routes that other clients have purchased their tickets for: